NpgRJ_NN_1944 1116..1124
نویسندگان
چکیده
Recent decades have witnessed tremendous advances in the neuroscience of emotion, learning and memory, and in animal models for understanding depression and anxiety. This review focuses on new rationally designed psychiatric treatments derived from preclinical human and animal studies. Nonpharmacological treatments that affect disrupted emotion circuits include vagal nerve stimulation, rapid transcranial magnetic stimulation and deep brain stimulation, all borrowed from neurological interventions that attempt to target known pathological foci. Other approaches include drugs that are given in relation to specific learning events to enhance or disrupt endogenous emotional learning processes. Imaging data suggest that common regions of brain activation are targeted with pharmacological and somatic treatments as well as with the emotional learning in psychotherapy. Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders.
منابع مشابه
Volume 22 Author Index
Aapro, Matti, 335–342 Abdel-Razeq, Hikmat, 1222–1231 AboElnazar, Essam, 1222–1231 Abou-Alfa, Ghassan K., 780–781 Abrams, Thomas A., 925–933 Adelstein, David, 1056–1066 Aderka, Dan, 804–810 Adje, Alex A., 189–198 Adjei, Brenda, 910–917 Adsay, Volkan, 1107–1116 Aggarwal, Charu, 700–708 Ahmed, Makhdum, 549–553 Ahn, Chul, 369–374 Ahn, Daniel H., 804–810 Ahn, Soomin, 1169–1177 Aitken, Katharine, 141...
متن کاملProperties of Azide - Catalase
Annau, E., Banga, I., Blazso, A., Brukner, V., Laki, K., Straub, F. B. & Szent-Gyorgyi, A. (1936). Hoppe-Seyl. Z. 244, 105. Annau, E., Banga, I., Gozsy, B., Huszak, S., Laki, K., Straub, F. B. & Szent-Gyorgyi, A. (1935). Hoppe-Seyl. Z. 236, 1. Annau, E. & Erd6s, T. (1939). IHoppe-Seyl. Z. 257, 111. Banga, I., Ochoa, S. & Peters, R. A. (1939). Biochem. J. 33, 1980. Das, N. B. (1937a). Biochem. J...
متن کاملPhosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain.
Phosphodiesterase 4 (PDE4) is an intracellular enzyme specifically degrading cAMP, a second messenger exerting inhibitory effects on many inflammatory cells. To investigate whether GPD-1116 (a PDE4 inhibitor) prevents murine lungs from developing cigarette smoke-induced emphysema, the senescence-accelerated mouse (SAM) P1 strain was exposed to either fresh air or cigarette smoke for 8 wk with o...
متن کاملProtein dynamics: whispering within.
Dynamic communication between atoms within folded proteins is potentially important for function, but its measurement has been a challenge. Now, a combined NMR and modelling study provides insights on the presence and strengths of such correlations.
متن کامل